An incurable disease which sees the immune system attack healthy tissue in the body, with hardening of the skin often one of the first noticeable symptoms, It generates excess collagen which can affect joints, tendons and internal organs and results in scarring, The milder form of the condition often starts with Raynaud's phenomenon - a circulation problem where fingers and toes turn white in the cold - and causes localised areas of skin to become hardened, The form of scleroderma Ms Virdee suffers from is called systemic sclerosis and affects internal organs, particularly the lungs, In total scleroderma affects 12,000 people in the UK to greatly varying degrees, It is four times more common in females than males, Scientists and doctors have not been able to establish what triggers the condition. Video, 'Vote him out': Trump booed at US Supreme Court, How Australia saved 70 stranded pilot whales. Ms Rainbow-Noack's diagnosis was the first time she and her family had heard of scleroderma and it galvanised them to raise awareness about the disease. She has had to convince sceptics she really is ill. A disabled parking badge in the car window and a heaving medicine cabinet are among the few visible clues of the suffering she endures. Although there is no cure for scleroderma, researchers at Virginia Mason Research Center and Duke University Medical Center are working with a stem cell procedure that has been shown to reverse the symptoms of the disease. Gripping her pen, typing and speaking for long periods were proving significant challenges. And so began three years of tests and consultations with various specialists before she received a formal diagnosis.

"I was so frustrated that these changes were happening, I thought I was a hypochondriac," Ms Rainbow-Noack said. This service may include material from Agence France-Presse (AFP), APTN, Reuters, AAP, CNN and the BBC World Service which is copyright and cannot be reproduced. "Walking, everything I did, it was so hard. Dr Richard Russell, a respiratory consultant at the Bridge Clinic in Maidenhead, says Ms Virdee's breathing has to be closely monitored.

Market data provided by Factset. They would see her out and about, seemingly going about her business as usual, but at the same time absent from her job. Without treatment she said she only had another three to five years to live. She enjoyed nothing more than going on holiday, and in that year she went on a trip to the Greek islands with her best friend Caroline. "If all goes well it would be great, but if anything happens I will know that I've had the best family — a father-in-law who looks after me, a husband who has been with me since I was 16 and two amazing daughters. "But whilst I still can, I'm going to smile as much as possible. Dr Maline Squance, chief executive of the Autoimmune Resource and Research Centre (ARRC) and former vice-president of Scleroderma Australia, said it could take a long time to diagnose the illness. "It is an invisible illness," she says.

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